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Knowing from post operative images where the electrode and the activated contact are, fiber tracts activated by DBS will be correlated to function and clinical data including electro-physiological signals acquired during surgery and clinical scores. For such purpose, we will propose a new adapted tractography approach from Diffusion Tensor Imaging. Additionally, we will study non-linear machine learning approaches to express such correlation and validate it on clinical data sets. The resulting models will allow both prediction and understanding of clinical outcome and side effects. | Knowing from post operative images where the electrode and the activated contact are, fiber tracts activated by DBS will be correlated to function and clinical data including electro-physiological signals acquired during surgery and clinical scores. For such purpose, we will propose a new adapted tractography approach from Diffusion Tensor Imaging. Additionally, we will study non-linear machine learning approaches to express such correlation and validate it on clinical data sets. The resulting models will allow both prediction and understanding of clinical outcome and side effects. | ||
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//Crossings of the pyramidal pathway with subthalamo-pallidal and pallido-subthalamic fibers (MC-det approach) in HCP subject 100307. Source: In vivo Exploration of the Connectivity between the Subthalamic Nucleus and the Globus Pallidus in the Human Brain Using Multi-Fiber Tractography, Pujol et al.// | //Crossings of the pyramidal pathway with subthalamo-pallidal and pallido-subthalamic fibers (MC-det approach) in HCP subject 100307. Source: In vivo Exploration of the Connectivity between the Subthalamic Nucleus and the Globus Pallidus in the Human Brain Using Multi-Fiber Tractography, Pujol et al.// |