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members:tristan.moreau:index [2014/09/29 13:56] tmoreau |
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====== PhD thesis : Emergence of a formal semantic description of human connectomics====== | ====== PhD thesis : Emergence of a formal semantic description of human connectomics====== | ||
- | ===== Abstract ===== | + | === Keywords === |
+ | Neuroinformatics, IRM, connectome, tractography, connectivity-based parcellation, web semantic, ontology, clustering. | ||
+ | |||
+ | == Abstract == | ||
Subdividing the cortex into structural elements, known as **parcellation**, is a key aspect to apprehend the link between structure and function in the brain. One of the main issue of parcellation is the compilation of the human cerebral **connectome** and could have important medical applications in medical image as better identify important functional areas to preserve in neurosurgery. | Subdividing the cortex into structural elements, known as **parcellation**, is a key aspect to apprehend the link between structure and function in the brain. One of the main issue of parcellation is the compilation of the human cerebral **connectome** and could have important medical applications in medical image as better identify important functional areas to preserve in neurosurgery. | ||
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Different aspects of human cerebral **structural connectivity** were investigated in this thesis using **diffusion Magnetic Resonance Imaging** (dMRI) and **tractography**, which is currently the unique technique that could reconstruct structural connectivity in vivo and non invasively. | Different aspects of human cerebral **structural connectivity** were investigated in this thesis using **diffusion Magnetic Resonance Imaging** (dMRI) and **tractography**, which is currently the unique technique that could reconstruct structural connectivity in vivo and non invasively. | ||
- | * A first study aimed to characterise short association bundles in the central region based on **diffusion tensor imaging** (DTI). | + | * A first study aimed to characterise short association bundles in the central region using a deterministic tractograhy. |
- | * A second study aimed to use structural connectivity to define a **connectivity-based-parcellation**. | + | * A second study aimed to define a **connectivity-based-parcellation** using probabilistic tractography. |
* Finally, the purpose of the last study was to create an applicative **ontology** in order to produce **semantic annotations** of connectional fingerprints based on **probabilistic tractography**. | * Finally, the purpose of the last study was to create an applicative **ontology** in order to produce **semantic annotations** of connectional fingerprints based on **probabilistic tractography**. | ||
- | This thesis gave me the opportunity to contribute to the developpment of **a neuroimaging tool box** called **taopy** (cf : [[:software|Software developpment]]). | + | This thesis gave me the opportunity to develop of **a neuroimaging tool box** called **taopy** (cf : [[:software|Software developpment]]). |
- | ===== Few results ===== | + | == Deterministic tractography in the central area == |
+ | {{:members:tristan.moreau:bundle.png|}} | ||
- | {{:members:tristan.moreau:high-resolution.png|}} | + | == Probabilistic tractography of corpus callosum == |
{{:members:tristan.moreau:diffusion.png|}} | {{:members:tristan.moreau:diffusion.png|}} | ||
{{:members:tristan.moreau:tracto.png|}} | {{:members:tristan.moreau:tracto.png|}} | ||
+ | == High-resolution cortical parcellation == | ||
+ | {{:members:tristan.moreau:high-resolution.png|}} | ||
+ | |||
+ | == Connectivity-based parcellation of SMA/pre-SMA == | ||
{{:members:tristan.moreau:ba6.png|}} | {{:members:tristan.moreau:ba6.png|}} | ||
- | {{:members:tristan.moreau:vsparql1.png|}} | + | |
- | {{:members:tristan.moreau:bundle.png|}} | + | == Connectivity-based parcellation of Broca areas == |
+ | {{:members:tristan.moreau:broca_connectivity_based_parcellation.png|}} | ||
+ | |||
+ | == Example of a vSparQL query on the reference ontology Foundational Model of Anatomy (FMA)== | ||
+ | {{:members:tristan.moreau:vpsarql_query.png|}} | ||
====== Teaching 2013-2014 at université Rennes1 ====== | ====== Teaching 2013-2014 at université Rennes1 ====== | ||
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====== Publications ====== | ====== Publications ====== | ||
+ | * Tristan Moreau, Bernard Gibaud, Ontology-based approach for in vivo human connectomics: the medial Brodmann area 6 case study, Fontiers in Neuroinformatics, 2015. | ||
* Elsa Magro, Tristan Moreau, Romuald Seizeur, Ilyess Zemmoura, Bernard Gibaud and Xavier Morandi. **Connectivity within the primary motor cortex:a DTI tractography study**, Surgical and Radiologic Anatomy,2014,36,125-135,http://dx.doi.org/10.1007/s00276-013-1160-y | * Elsa Magro, Tristan Moreau, Romuald Seizeur, Ilyess Zemmoura, Bernard Gibaud and Xavier Morandi. **Connectivity within the primary motor cortex:a DTI tractography study**, Surgical and Radiologic Anatomy,2014,36,125-135,http://dx.doi.org/10.1007/s00276-013-1160-y | ||
* Tristan Moreau, Bernard Gibaud. **Connectivity-based parcellation of the | * Tristan Moreau, Bernard Gibaud. **Connectivity-based parcellation of the |